Public healthGenetically engineered bacteria prevent mosquitoes from transmitting malaria
Malaria kills more than 800,000 people worldwide each year, many are children; researchers have genetically modified a bacterium commonly found in the mosquito’s midgut and found that the parasite that causes malaria in people does not survive in mosquitoes carrying the modified bacterium
Genetically altered bacterium kills parasite that causes malaria // Source: janatantra.com
Researchers at the Johns Hopkins Malaria Research Institute have genetically modified a bacterium commonly found in the mosquito’s midgut and found that the parasite that causes malaria in people does not survive in mosquitoes carrying the modified bacterium. The bacterium, Pantoea agglomerans, was modified to secrete proteins toxic to the malaria parasite, but the toxins do not harm the mosquito or humans. According to a study published by Proceedings of the National Academy of Sciences, the modified bacteria were 98 percent effective in reducing the malaria parasite burden in mosquitoes.
“In the past, we worked to genetically modify the mosquito to resist malaria, but genetic modification of bacteria is a simpler approach,” said Marcelo Jacobs-Lorena, Ph.D., senior author of the study and a professor with Johns Hopkins Bloomberg School of Public Health. “The ultimate goal is to completely prevent the mosquito from spreading the malaria parasite to people.”
A Johns Hopkins University Bloomberg School of Public Health release reports that with the study, Jacobs-Lorena and his colleagues found that the engineered P. agglomerans strains inhibited development of the deadliest human malaria parasite Plasmodium falciparum and rodent malaria parasite Plasmodium berghei by up to 98 percent within the mosquito. The proportion of mosquitoes carrying parasites (prevalence) decreased by up to 84 percent.
“We demonstrate the use of an engineered symbiotic bacterium to interfere with the development of P. falciparum in the mosquito. These findings provide the foundation for the use of genetically modified symbiotic bacteria as a powerful tool to combat malaria,” said Jacobs-Lorena.
Malaria kills more than 800,000 people worldwide each year. Many are children.
The research was supported by National Institute of Allergy and Infectious Diseases, the Bill & Melinda Gates Foundation, the Johns Hopkins Malaria Research Institute and the Bloomberg Family Foundation.
— Read more in Sibao Wang et al., “Fighting malaria with engineered symbiotic bacteria from vector mosquitoes,” Proceedings of the National Academy of Sciences (16 July 2012) (doi: 10.1073/pnas.1204158109)
